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EXPERIENCE AND KNOWLEDGE IS IMPORTANT IN MEDICAL TRANSLATION
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Eingereichte Übersetzungsbeispiele: 1
Türkisch > Englisch: Drug Prescription General field: Medizin
Ausgangstext - Türkisch XXXX xmg çentikli film tablet
FORMÜLÜ
Her bir çentikli film tablet x mg olanzapin ve boyar madde
olarak titanyum dioksit içerir.
FARMAKOLOJİK ÖZELLİKLERİ
Farmakodinamik özellikleri
Olanzapin, bir grup reseptör üzerinde etki gösteren antipsikotik, antimanik ve duygudurum düzenleyici bir üründür. Olanzapin, serotonin 5HT2A/2C, 5HT3, 5HT6; dopamin D1, D2, D3, D4, D5; kolinerjik muskarinik M1-M5 reseptörleri; alfa1 adrenerjik; ve histamin H1 reseptörleri'ne afinite gösterir (Ki
Übersetzung - Englisch XXXXX x mg scored film-coated tablet
COMPOSITION
Each scored film-coated tablet contains x mg olanzapine and titanium dioxyde as coloring agent.
Olanzapine is an antipsychotic, antimanic and mood regulating product that affects on a group of receptors. Olanzapine shows affinity for 5HT 2A/2C, 5HT3, 5HT6, dopamine D1, D2, D3, D4, D5, cholinergic muscarinic M1-M5 receptors; alpha adrenergic and histamine H1 receptors (Ki>100nM). 5HT, dopamine and cholinergic antagonism were shown complying with receptor binding profile in animal studies. Affinity of olanzapine for serotonin 5HT2 receptors is higher tna for dopamine D2 receptors. Electrophysiologic studies showed that olanzapine selectively decreases dopaminergic neuron stimulation and has a very low effect on striatal paths efficient on motor functions. Olanzapine decreases the conditioned aversion response which is an indicator for antipsychotic efficiency in doses under levels that reveal catalepsy, a symptom of motor side effects. Unlike from some other antipsychotics, olanzapine increases the response to anxiolytic tests. It was shown that olanzapine regulates either positive or negative symptoms of schizophrenia significantly.
Pharmacokinetic Properties
Absorption
Olanzapine is well absorbed following oral use and peak plasma concentration is obtained within 5-8 hours. Absorption is not affected by food. Oral bioavailability is about 57%.
Distribution
In 7-1000 ng/ml concentration, olanzapine plasma protein binding is 93% (mainly albumin and alpha 1- acide-glucoporotein)
Elimination
Olanzapine is metabolized by conjugation and oxidation in liver. First pass elimination is 40%. Basic metabolite in the circulation is 10-N-glucuronide which can not pass through the blood-brain barrier. Cyctochrome P450 CYP 1A2 and CYP 2D6 enzymes provides formation of N-desmetil and 2-hydroxymetil metabolites. Both of these metabolites showed lower in vivo pharmacological efficiency than olanzapine in animal studies. Olanzapine is responsible from basic pharmacological efficiency.
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Erfahrung
Übersetzungserfahrung in Jahren: 26. Angemeldet bei ProZ.com seit: Mar 2008.
Help or teach others with what I have learned over the years
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Lebenslauf
Excellent knowledge combines with experince in medical translation.
Medical translation requires excellent knowledgeand experience on medicine and language. Therefore, medical texts should be tranalsted by translators who have been trained in this field.
Since my translation journeyhas started in Medical School in USA,in 1996, I combined my language skills with medical education. I translate, edit and proofread medical articles and researches to be published by reputable medical journals in the world.
My areas of expertise in medical translation are as follows:
-Pharmaceutical documents such as CTD reports preparation, translation and editing,
-Medical device translation, editing
-Patient reports translation
-Medical reseraches and thesis translation, editing
-All documents needed to be translated in medical departments such as informed consent forms, articles and similar documents.
I would be happy to serve as a translator to provide excellent medical translation experience in my language pairs; English <> Turkish and German <> Turkish.
Schlüsselwörter: English<>Turkish, medical translator, physician, pharmaceuticals
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