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Englisch > Italienisch: Sample for an article in TIME magazine, 12 September 2016
Ausgangstext - Englisch Tarnopolsky has published some of those papers himself. In 2011, he and a team studied mice with a terrible genetic disease that caused them to age prematurely. Over the course of five months, half of the mice were sedentary. The other half were coaxed to run three times a week on a miniature treadmill.
By the end of the study, the sedentary mice were barely hanging on. The fur that had yet to fall out had grown coarse and gray, muscles shriveled, hearts weakened, skin thinned–even the mice’s hearing got worse. “They were shivering in the corner, about to die,” Tarnopolsky says.
But the group of mice that exercised, genetically compromised though they were, were nearly indistinguishable from healthy mice. Their coats were sleek and black, they ran around their cages, they could even reproduce. “We almost completely prevented the premature aging in the animals,” Tarnopolsky says.
That’s remarkable news, if you’re a mouse. And though there are obvious differences between rodents and humans, Tarnopolsky has seen something similar happen in his ill patients. “I’ve seen all the hype about gene therapy for people with genetic disease”–Tarnopolsky treats kids with severe genetic diseases like muscular dystrophy–“but it hasn’t delivered in the 25 years I’ve been doing this,” he says. “The most effective therapy available to my patients right now is exercise.”
Übersetzung - Italienisch Tarnopolsky è l’autore di alcuni di questi studi. Nel 2011 lui e la sua equipe hanno studiato un campione di topi affetti da una terribile malattia genetica che causa l’invecchiamento precoce. Per 5 mesi alla metà di questi topi è stata fatta condurre una vita sedentaria, mentre l’altra metà veniva indotta a correre su un tapis roulant in miniatura per tre volte alla settimana.
Alla fine del periodo di studio, i topi “sedentari” a fatica riuscivano a muoversi. Il loro pelo, se non era ormai caduto, si mostrava ruvido e grigio, i muscoli erano atrofizzati, il cuore indebolito e la pelle assottigliata. Persino il loro udito era peggiorato. “Se ne stavano tremolanti in un angolo, aspettando di morire”, riferisce Tarnopolsky.
Il gruppo di topi sottoposti ad esercizio invece, sebbene soffrisse della stessa compromissione a livello genetico, non era distinguibile da campioni di topi sani. I topi “allenati” avevano manto lucido e nero, si muovevano velocemente e addirittura si riproducevano. “Siamo stati in grado di impedire quasi totalmente l’invecchiamento precoce in questi animali” afferma il neuroscienziato. E questa è una buona notizia, specialmente se sei un topo. Sebbene vi siano delle ovvie differenze tra roditori ed umani, Tarnopolsky ha notato che qualcosa di simile accade ai suoi pazienti malati. “Nei miei 25 anni di attività, ho visto offrire ogni tipo di terapia genica alle persone colpite da malattie genetiche,”- Tarnopolsky cura bambini con malattie genetiche gravi, come la distrofia muscolare- “ma nessuna di queste ha alleviato le condizioni di vita dei pazienti. La terapia più efficace ad oggi disponibile per i miei pazienti è l’attività fisica.”
Englisch > Italienisch (Educational Testing Service - TOEFL, verified) Englisch > Italienisch (Consorzio interuniversitario Italian Culture on the Net) Englisch > Italienisch (Università di Pisa, verified) Englisch > Italienisch (Universitat de València (Facultat de Filologia)) Englisch > Italienisch (University College London)
Englisch > Italienisch (Universita' degli Studi di Genova, verified) Spanisch (Universitat de València (Facultat de Filologia), verified) Englisch (Universitat de València (Facultat de Filologia), verified) Englisch > Italienisch (University of Roehampton, verified) Spanisch > Italienisch (Universidad de Valencia)
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